报告题目：G30 graduate programs (9:30 am)
Scientific discussions: Wonder of protein, life within the cell (10:00am)
报 告 人：Prof. Toshiya Endo
报告时间：2011年9月9日上午
报告地点：生物药学楼3号楼105
组织单位：hbs红宝石平台
报告摘要：
Proteins mediate nearly all the biological processes in cells.  A protein molecule is a linear chain of 20 different amino acids, the sequence of which is specified by its gene.  The life of a protein in the cell starts from its synthesis in the ribosome.  The protein then undergoes many events and processes leading to its maturation, which include transport to the site of its function and folding and assembly into a unique structure that determines its function.  Since the functional state of the protein is always under surveillance, it will be cured when it becomes defective.  If it cannot be fixed any more or when it reaches the time for termination, the protein ends its life by degradation into amino acids.  This lecture introduces the recent knowledge on the molecular basis of the sophisticated cellular systems that mediate those processes and biological consequences of their system failure, which may often lead to human diseases.

报告人简介：
TOSHIYA ENDO
Curriculum vitae (June, 2011)

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Toshiya Endo is a professor of Department of Chemistry, Graduate School of Science, Nagoya University.  He received his PhD degree for his NMR study on snake neurotoxins at Department of Biochemistry and Biophysics, Faculty of Science, the University of Tokyo in 1982.  He became an assistant professor at Department of Chemistry, College of Technology, Gunma University in 1982, was promoted to an associate professor of the same department in 1987, and then became an associate professor of Department of Biological and Chemical Engineering, Faculty of Engineering, Gunma University in 1989.  In the meantime (1986-1988), he was a visiting scientist at Biocenter, the University of Basel, Switzerland, where he joined Jeff Schatz’s group to start his work on protein import into mitochondria.  In 1989, he moved to Nagoya University to become a PI as an associate professor at Department of Chemistry, Faculty of Science, Nagoya University, and became a full professor in 1991 at the same department.  In 1996, he became a professor of Department of Chemistry, Graduate School of Science, Nagoya University.  In 2003-2008, he was a project-based faculty of the Institute for Advanced Research, Nagoya University.  He is now the leader of the Grant-in-Aid for Scientific Research in Priority Area from MEXT, ‘Protein Community’.


EDUCATION
1977 B.S., Biochemistry and Biophysics, the University of Tokyo
1982 Ph. D., Biochemistry and Biophysics, the University of Tokyo
Research Advisor: Professor Tatsuo Miyazawa
Thesis Title: “Proton Nuclear Magnetic Resonance Studies on Molecular Conformations of Snake Neurotoxins”

PROFESSIONAL
1982-1987 Assistant Professor: Department of Chemistry, Gunma University
1986-1988 Visiting Scientist: Biocenter, the University of Basel
1987-1989 Associate Professor: Department of Chemistry, Gunma University
1989-1991 Associate Professor: Department of Chemistry, Nagoya University
1991-present Professor: Department of Chemistry, Graduate School of Science, Nagoya University
2003-present Assistant Dean (Graduate School of Science, Nagoya University)
2009-present   Presidential Advisor (Nagoya University)
2010-present   Program Officer (Research Center for Science Systems, JSPS (Japan Society for the Promotion of Science))

AWARDS
1998 IBM Scientific Award in Chemistry (IBM Japan)

OTHER ACTIVITIES
2005-2007  Director, the Japanese Biochemical Society
2006-2008  Director, the Japanese Society of Protein Science
2007-2008  Head of the Chubu Branch, the Japanese Biochemical Society
2002-2005  Associate Editor, the Journal of Biochemistry (Japanese Biochemical Society)
1988-2006  Editorial Board, the Protein Journal (the Journal of Protein Chemistry) (Kluwer Academic/Plenum Publishing Co.)
2001- present Editorial Board, Cell, Structure and Function (Japanese Society for Cell Biology)
2005-2006  Associate Editor, Cell, Structure and Function (Japanese Society for Cell Biology
2009- present Presidential Advisor
2010- present Program Officer of Research Center for Science Systems at JSPS

SELECTED PUBLICATIONS
H. Yamamoto, N. Itoh, S. Kawano, Y. Yatsukawa, T. Momose, T. Makio, M. Matsunaga, M. Yokota, M. Esaki, T. Shodai, D. Kohda, A.E.A. Hobbs, R.E. Jensen, and T. Endo
Dual role of the receptor Tom20 in specificity and efficiency of protein import into mitochondria
Proc. Natl. Acad. Sci. USA 108, 91-96 (2011)
D. Maruyama, T. Endo, and S. Nishikawa
Bip-mediated polar nuclei fusion is essential for the regulation of endosperm nuclei proliferation in Arabidopsis thaliana.
Proc. Natl. Acad. Sci. USA 107, 1684-1689 (2010)
S. Kawano, K. Yamano, M. Naoe, T. Momose, K. Terao, S. Nishikawa, N. Watanabe, and T. Endo
Structural basis of yeast Tim40 as an oxidative translocator in the mitochondrial intermembrane space
Proc. Natl. Acad. Sci. USA 106, 14403-14407(2009)
Y. Tamura, Y. Harada, T. Shiota, K. Yamano, K. Watanabe, M. Yokota, H. Yamamoto, H. Sesaki, and T. Endo
Tim23-Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import.
J. Cell Biol. 184, 129-141 (2009)
Y. Tamura, Y. Harada, K. Yamano, K. Watanabe, D. Ishikawa, C. Ohshima, S. Nishikawa, H. Yamamoto, and T. Endo
Identification of Tam41 maintaining integrity of the TIM23 protein translocator complex in mitochondria
J. Cell Biol. 174, 615-623(2006)
T. Sato, M. Esaki, J. M.Fernandez, and T. Endo
Comparison of the protein unfolding pathways between mitochondrial protein import and atomic force microscopy measurements
Proc. Natl. Acad. Sci. USA 102, 17999-18004 (2005)
A. Takano, T. Endo, and T. Yoshihisa
tRNA actively shuttles between the nucleus and cytosol in yeast.
Science 309, 140-142 (2005)
D. Ishikawa, H. Yamamoto, Y. Tamura, K. Moritoh, and T. Endo
Two novel proteins in the mitochondrial outer membrane mediate β-barrel protein assembly
J. Cell Biol. 166, 621-627 (2004)
M. Esaki, T. Kanamori, S. Nishikawa, I. Shin, P. G. Schultz, and T. Endo
Tom40 protein import channel binds to non-native proteins and prevents their aggregation
Nature Struct. Biol. 10, 988-994 (2003)
H. Yamamoto, M. Esaki, T. Kanamori, Y. Tamura, S. Nishikawa, and T. Endo :
Tim50 is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes
Cell 111, 519-528 (2002)
S. Nishikawa, S. W. Fewell, Y. Kato, J. L. Brodsky, and T. Endo
Molecular chaperones in the yeast ER maintain the solubility of proteins for retro-translocation and degradation.
J. Cell Biol. 153, 1061-1070 (2001)
Y. Abe, T.Shodai, T. Muto, K. Mihara, H. Torii, S. Nishikawa, T. Endo, and D. Kohda
Structural basis of presequence recognition by the mitochondrial protein receptor Tom20
Cell 100, 551-560 (2000)
M. Esaki, T. Kanamori, S. Nishikawa, and T. Endo
Two distinct mechanisms drive protein translocation across the mitochndrial outer membrane in the late step of the cytochrome b2 import pathway
Proc. Natl. Acad. Sci. USA 96, 11770-11775 (1999)
T. Kanamori, S. Nishikawa, M. Nakai, I. Shin, P. G. Schultz, and T. Endo
Uncoupling of transfer of the presequence and unfolding of the mature domain in precursor translocation across the mitochondrial outer membrane
Proc. Natl. Acad. Sci. USA 96, 3634-3639 (1999)