报告题目：Molecular and Cellular Mechanisms of Stem Cell Aging

报  告 人：秦昭，同济大学医学院教授，博士生导师。

报告时间： 6月22日  14:00-15:00

报告地点：闵行校区生物药学楼三号楼2层教工之家

联  系 人：谢云 34207401

报告人简介：秦昭，同济大学医学院教授，博士生导师。2004年毕业于上海交通大学，获生物技术系学士学位。2010年毕业于美国密歇根大学，获分子细胞发育生物学系博士学位。博士期间以斑马鱼为模型，研究神经再生的分子机制。2010年至2016年在美国纽约大学医学院进行博士后训练，以线虫的生殖干细胞为模型，从事干细胞衰老机制的研究工作。秦昭教授的实验室运用线虫和小鼠等模式动物研究衰老机制，主要关注生殖系统和神经系统：包括生殖干细胞和神经干细胞的衰老机制、生殖衰老（卵细胞质量控制等）的机制、神经退行性疾病的致病机理和治疗手段的研究。

报告简介：Stem cells maintain tissues and organs over the lifespan of individuals. Consequently, age-associated stem cell decline affects the normal function and regenerative capacity of many tissues and organ systems, contributing to aging at the organismal level. Therefore, a better understanding of the molecular and cellular control of stem cell aging is required. My lab uses the C. elegans germ line as a model to study the effect of age on stem cells. Previous work from my postdoc studies showed that reducing insulin/IGF-1 signaling suppresses age-related loss of germline stem cells and that this effect requires the downstream FOXO transcription factor DAF-16. Surprisingly, DAF-16/FOXO is required in cells at the proximal region of the somatic gonad, a region that contacts the differentiated progeny of germline stem cells, suggesting a novel mechanism of stem cell regulation at the organ system level. In my own lab, I plan to investigate the nature of germline stem cell regulation by DAF16/FOXO activity in the proximal somatic gonad and to identify and characterize new genes that regulate age-related germline stem cell loss. Together, we hope our studies will not only greatly advance our understanding of the mechanisms that underlie age-related germline stem cell loss in C. elegans, but also contribute to our knowledge of stem cell aging in general.