讲座时间：2020年11月11日上午9:30

讲座地点：上海交通大学闵行校区 生命药学楼树华报告厅

主 讲 人：魏文胜 北京大学生命科学技术学院

主办单位：生命科学技术学院

联 系 人：邢海娜 (xinghaina@sjtu.edu.cn)

主讲人简介：

魏文胜，北京大学生命科学学院教授，目前同时担任北京大学生物医学前沿创新中心（BIOPIC）、北京未来基因诊断高精尖创新中心（ICG）及北大-清华生命科学联合中心（CLS）研究员，任北京大学基因组编辑研究中心主任。课题组致力于发展基于基因组编辑技术的高通量功能基因组学、开发新型基因编辑技术并应用于基因治疗，研究癌症、感染等重大疾病发生机制，为发展高效治疗手段提供新的药物靶点和思路。

内容简介：

We have previously developed a series of high-throughput screening (HTS) methods based on CRISPR/Cas9 system for the functional identification of protein-coding genes and long non-coding RNAs. We have also re-designed sgRNA scaffold that greatly boosts the efficiency and data quality for HTS. Our recent efforts include the identification of functional 3D-hubs that were essential for cell viability, the development of a new approach for mapping functional sites of protein of interest at single amino acid resolution, and a series of novel high-throughput strategies derived from base editors. Besides these high-throughput strategies to facilitate the accurate and rapid identification of functional genomic elements in various settings, we have recently developed a novel programmable RNA editing strategy called LEAPER. Unlike conventional nucleic acid editing technology that requires simultaneous delivery of editing enzymes (such as Cas protein) and guide RNAs into cells, LEAPER enables precise and efficient RNA editing by recruiting endogenous cellular deaminase using engineered RNAs.  

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